The implementation of a highly flexible CIP system, including transfer lines, transfer panels, and return pump. The target equipment was a set of compounding tanks and transfer pumps and lines used to compound a variety of liquid pharmaceutical preparations of various properties. Key flexible features:
Design, Drawings Specifications
Project Management
Commissioning
The installation of a freeze drier in a biologics plant for the lyophilization of the sterile finished product. Cheme designed, managed the construction of, a freeze drier for the processing of sterile biologic products.
The scope included engineering of all support utilities required for the freeze drier including compressed air, liquid nitrogen, clean steam and other gray utilities. The piece of equipment was imported from China and all dimensional and installation co-ordination for the unit was carried out by Cheme.
Design, Drawings Specifications
Project Management
(C&Q by Owner)
A fully customized compounding and sterile filtration system. Key features and project challenges:
Design, Drawings Specifications
Project Management
Training, SOP and other operating documents preparation
Commissioning
Validation
A small volume high potency facility required a clean steam and WFI systems on a very tight schedule. A used clean steam generator was rehabilitated for clean steam production and the WFI was generated by clean steam condensing.
Project highlights:
Design, Drawings Specifications
Project Management
Training
Commissioning
Validation
A blood plasma fractionation process was installed at a contract manufacturing facility. Cheme acted as the Owners engineering representative throughout the project.
Technology transfer
Design review
Commissioning and Validation of 3 units