Modern tank storage for production

Projects | Pharmaceutical

OSD Facility Expansion Project

Pharmaceutical Manufacturing Expansion for Oral Solid Dose Production

A Canadian pharmaceutical client needed to expand manufacturing capabilities for oral solid dose production. Cheme provided design and engineering services, project management, and commissioning and qualification (C&Q) services to support our client’s execution of the manufacturing expansion. Cheme was responsible for several processes and systems including:

  • A custom-engineered bulk (>4000 gal) solvent storage and distribution system with temperature control 
  • A Wash-in-Place (WIP) system for the cleaning of process equipment
  • Critical Utilities systems expansion for the production suites and process equipment

Our client sought to eliminate drum-based handling of methanol through implementation of a bulk storage and distribution system to improve operator safety, increase quality and reliability, as well as reduce costs. The bulk solvent storage and distribution system was designed to meet local fire and building codes. The storage tank was equipped with a nitrogen blanketing system and an automatic marshaling system for methanol dispensing to users throughout the facility.

The WIP system was designed for cleaning process equipment including a fluid bed, coating pan, transfer lines, and associated peripherals such as dip tubes, mixers, and transfer panels. The system was automated and equipped with recipe management utilizing ISA S88. Cheme was also responsible for the critical utility systems expansion to increase production capacity in various new suites. The development of compact solutions was necessary to fit within tight spatial constraints while ensuring coordination with all project stakeholders. 

Our experienced team anticipated many potential risks which were avoided through detailed and often creative planning.

Project Snapshot

Location

Ontario, Canada

Project Type

OSD Facility Expansion

Expert Spotlight

Melissa Zacher

Infrastructure Development Leader, Principal

Melissa is a Principal at Cheme Engineering with over 10 years of leadership, project management and engineering experience in the life sciences sector.
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As an engineering service provider, Cheme not only offers a deep bench of knowledge and experience but a top notch team of professionals who truly stand out and embody the core values of Cheme. Our clients are the reason why we do what we do and we strive to develop long-lasting collaborative relationships with our clients built on trust and integrity.

Trevor Williams

Talent Acquisition Leader, Process Engineer, Project Manager

Trevor is on the front line helping clients solve problems in his roles as a process engineer and project manager, and brings extensive experience to the table within the pharmaceutical, botanicals, food and nuclear industries.
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Cheme has the experience, dedication and knowledge to help with any project. We focus on each project and ‘sweat the small stuff’ so you can focus on your job. Cheme is the worry-free solution for your next project.

Lauren Box

Project Manager

Lauren is a Project Manager with over 9 years of experience in single use technology, ultrafiltration systems, clean in place systems and clean utilities, and municipal and industrial water and wastewater treatment.
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Cheme provides full engineering and project management services, acting as a liaison between all stakeholders to ensure smooth project implementation.

Melissa Zacher

Infrastructure Development Leader, Principal

Trevor Williams

Talent Acquisition Leader, Process Engineer, Project Manager

Lauren Box

Project Manager

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