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Projects | Biotechnology

Vaccine Manufacturing Process Upgrades Project

Vaccine Production Sustainability 

Our client in the biotechnology industry retained Cheme to design, optimize, implement, and validate their existing biologic manufacturing process. New processes and equipment replaced aging and obsolete equipment and installed in their existing facility. Five critical process steps were completely redesigned, while two additional utility systems were refurbished and automated.

Although process requirements were largely defined by the existing process parameters and specifications, the client gave Cheme substantial creative freedom to design new systems. These systems were optimized to reduce processing times, enhance containment and biosafety, and maximize ease of operation.

Cheme provided conceptual design, detailed design, procurement, project management, commissioning, and validation services for all five process systems and two utility systems. The novel manufacturing process was built in the client’s existing facility, including systems such as clarification, sterile filtration, stainless steel and single-use vessels, ultrafiltration, and automated clean utility distribution.

Highlights of this project’s success include outstanding reviews from operations staff in terms of ergonomics and ease of use, and a near-doubling of the product titer compared to the previous process. Additionally, compliance with modern standards for data integrity, biocontainment, and equipment cleaning were not only enhanced, but now hold the standard for the client’s expectations for future projects.

Project Snapshot

Location

Ontario, Canada

Square Footage of Project

3000 sqft

Project Type

Vaccine Manufacturing Process Upgrades

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Rino Parletta

Vice President, Principal

Rino is the Vice President of Cheme Engineering, playing a key role in business strategy, management of operations, delivery of professional services, financial performance and future growth of the firm.
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Chris Defina

Regional East Studio Head, Principal

Chris is a Principal and the Regional East Studio Head at Cheme Engineering and has been with the company for 10 years. Since becoming a shareholder in 2017, he has been a key contributor to the growth, management and success of the organization.
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At Cheme, we are focused on establishing strong partnerships built on trust, communication, and an understanding of the unique needs of our clients. When we take on a project, we don’t compromise any of these aspects. When you work with Cheme, you can have the confidence that you’ve chosen a partner that won’t let you down.

Lauren Box

Regional West Studio Head

Lauren is the Regional West Studio Head with over 9 years of experience in single use technology, ultrafiltration systems, clean in place systems and clean utilities, and municipal and industrial water and wastewater treatment.
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Cheme provides full engineering and project management services, acting as a liaison between all stakeholders to ensure smooth project implementation.

Rino Parletta

Vice President, Principal

Chris Defina

Regional East Studio Head, Principal

Lauren Box

Regional West Studio Head

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