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Projects | Biotechnology

Vaccine Manufacturing Process Upgrades Project

Vaccine Production Sustainability 

Our client in the biotechnology industry retained Cheme to design, optimize, implement, and validate their existing biologic manufacturing process. New processes and equipment replaced aging and obsolete equipment and installed in their existing facility. Five critical process steps were completely redesigned, while two additional utility systems were refurbished and automated.

 Although process requirements were largely defined by the existing process parameters and specifications, the client gave Cheme substantial creative freedom to design new systems. These systems were optimized to reduce processing times, enhance containment and biosafety, and maximize ease of operation.

Cheme provided conceptual design, detailed design, procurement, project management, commissioning, and validation services for all five process systems and two utility systems. The novel manufacturing process was built in the client’s existing facility, including systems such as clarification, sterile filtration, stainless steel and single-use vessels, ultrafiltration, and automated clean utility distribution.

 Highlights of this project’s success include outstanding reviews from operations staff in terms of ergonomics and ease of use, and a near-doubling of the product titer compared to the previous process. Additionally, compliance with modern standards for data integrity, biocontainment, and equipment cleaning were not only enhanced, but now hold the standard for the client’s expectations for future projects.

Project Snapshot


Ontario, Canada

Square Footage of Project

3000 sqft

Project Type

Vaccine Manufacturing Process Upgrades

Expert Spotlight

Rino Parletta

Vice President, Principal

Rino is the Vice President of Cheme Engineering, playing a key role in business strategy, management of operations, delivery of professional services, financial performance and future growth of the firm.
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At Cheme, we bring the resources and expertise of a large firm and the care and attention of a small firm together to serve every client as a dedicated partner.

Chris Defina

Client Technical Services Leader, Project Manager, Principal

Chris is a Principal at Cheme Engineering and has been with the company for 10 years. Since becoming a shareholder in 2017, he has been a key contributor to the growth, management and success of the organization.
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At Cheme, we are focused on establishing strong partnerships built on trust, communication, and an understanding of the unique needs of our clients. When we take on a project, we don’t compromise any of these aspects. When you work with Cheme, you can have the confidence that you’ve chosen a partner that won’t let you down.

Rino Parletta

Vice President, Principal

Chris Defina

Client Technical Services Leader, Project Manager, Principal

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